Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 902302..902956 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDU34_RS04465 Protein ID WP_000244777.1
Coordinates 902549..902956 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDU34_RS04460 Protein ID WP_000354046.1
Coordinates 902302..902568 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS04435 (897471) 897471..898214 + 744 WP_241214140.1 SDR family oxidoreductase -
QDU34_RS04440 (898271) 898271..899704 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QDU34_RS04445 (899749) 899749..900060 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QDU34_RS04450 (900224) 900224..900883 + 660 WP_000250274.1 hemolysin III family protein -
QDU34_RS04455 (901079) 901079..902059 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QDU34_RS04460 (902302) 902302..902568 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDU34_RS04465 (902549) 902549..902956 + 408 WP_000244777.1 protein YgfX Toxin
QDU34_RS04470 (902996) 902996..903517 - 522 WP_001055870.1 flavodoxin FldB -
QDU34_RS04475 (903629) 903629..904525 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDU34_RS04480 (904550) 904550..905260 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDU34_RS04485 (905266) 905266..906999 + 1734 WP_128995306.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T278568 WP_000244777.1 NZ_CP123046:902549-902956 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278568 WP_000354046.1 NZ_CP123046:902302-902568 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References