Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5355958..5356583 Replicon chromosome
Accession NZ_CP123043
Organism Klebsiella pneumoniae strain KP161637

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QDF61_RS25985 Protein ID WP_002882817.1
Coordinates 5355958..5356341 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QDF61_RS25990 Protein ID WP_004150355.1
Coordinates 5356341..5356583 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDF61_RS25970 (5353324) 5353324..5354226 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QDF61_RS25975 (5354223) 5354223..5354858 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QDF61_RS25980 (5354855) 5354855..5355784 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QDF61_RS25985 (5355958) 5355958..5356341 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QDF61_RS25990 (5356341) 5356341..5356583 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QDF61_RS25995 (5356788) 5356788..5357705 + 918 WP_004178029.1 alpha/beta hydrolase -
QDF61_RS26000 (5357719) 5357719..5358660 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QDF61_RS26005 (5358705) 5358705..5359142 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QDF61_RS26010 (5359139) 5359139..5359999 - 861 WP_004146232.1 virulence factor BrkB family protein -
QDF61_RS26015 (5359993) 5359993..5360592 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T278563 WP_002882817.1 NZ_CP123043:c5356341-5355958 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT278563 WP_004150355.1 NZ_CP123043:c5356583-5356341 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References