Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5031977..5033658 Replicon chromosome
Accession NZ_CP123043
Organism Klebsiella pneumoniae strain KP161637

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag QDF61_RS24475 Protein ID WP_004146663.1
Coordinates 5031977..5032894 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag QDF61_RS24480 Protein ID WP_004177809.1
Coordinates 5032900..5033658 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDF61_RS24455 (5027283) 5027283..5028803 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
QDF61_RS24460 (5028800) 5028800..5029798 + 999 WP_002885172.1 ribose ABC transporter permease -
QDF61_RS24465 (5029829) 5029829..5030770 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
QDF61_RS24470 (5030845) 5030845..5031852 + 1008 WP_004177805.1 carbohydrate kinase family protein -
QDF61_RS24475 (5031977) 5031977..5032894 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QDF61_RS24480 (5032900) 5032900..5033658 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QDF61_RS24485 (5033744) 5033744..5034472 - 729 WP_004177810.1 response regulator transcription factor -
QDF61_RS24490 (5034745) 5034745..5036892 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
QDF61_RS24495 (5036889) 5036889..5037032 - 144 WP_022631365.1 hypothetical protein -
QDF61_RS24500 (5037238) 5037238..5037924 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T278562 WP_004146663.1 NZ_CP123043:c5032894-5031977 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT278562 WP_004177809.1 NZ_CP123043:c5033658-5032900 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2XCI1

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References