Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4876263..4876779 Replicon chromosome
Accession NZ_CP123043
Organism Klebsiella pneumoniae strain KP161637

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag QDF61_RS23685 Protein ID WP_009486548.1
Coordinates 4876263..4876547 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QDF61_RS23690 Protein ID WP_002886901.1
Coordinates 4876537..4876779 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDF61_RS23660 (4871659) 4871659..4871922 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QDF61_RS23665 (4872052) 4872052..4872225 + 174 WP_004222159.1 hypothetical protein -
QDF61_RS23670 (4872228) 4872228..4872971 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QDF61_RS23675 (4873328) 4873328..4875466 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QDF61_RS23680 (4875795) 4875795..4876259 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QDF61_RS23685 (4876263) 4876263..4876547 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDF61_RS23690 (4876537) 4876537..4876779 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QDF61_RS23695 (4876857) 4876857..4878766 - 1910 Protein_4647 PRD domain-containing protein -
QDF61_RS23700 (4878789) 4878789..4879943 - 1155 WP_004178372.1 lactonase family protein -
QDF61_RS23705 (4880010) 4880010..4880750 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T278561 WP_009486548.1 NZ_CP123043:c4876547-4876263 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT278561 WP_002886901.1 NZ_CP123043:c4876779-4876537 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References