Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4769341..4770151 Replicon chromosome
Accession NZ_CP123043
Organism Klebsiella pneumoniae strain KP161637

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QDF61_RS23185 Protein ID WP_004178461.1
Coordinates 4769341..4769874 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QDF61_RS23190 Protein ID WP_002887278.1
Coordinates 4769885..4770151 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDF61_RS23180 (4768172) 4768172..4769293 + 1122 WP_033128569.1 cupin domain-containing protein -
QDF61_RS23185 (4769341) 4769341..4769874 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QDF61_RS23190 (4769885) 4769885..4770151 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QDF61_RS23195 (4770254) 4770254..4771687 - 1434 WP_020804438.1 Cu(+)/Ag(+) sensor histidine kinase -
QDF61_RS23200 (4771677) 4771677..4772360 - 684 WP_020804437.1 copper response regulator transcription factor CusR -
QDF61_RS23205 (4772532) 4772532..4773917 + 1386 WP_020804440.1 efflux transporter outer membrane subunit -
QDF61_RS23210 (4773935) 4773935..4774279 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T278560 WP_004178461.1 NZ_CP123043:c4769874-4769341 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT278560 WP_002887278.1 NZ_CP123043:c4770151-4769885 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References