Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2698367..2699955 Replicon chromosome
Accession NZ_CP123043
Organism Klebsiella pneumoniae strain KP161637

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag QDF61_RS13275 Protein ID WP_016529318.1
Coordinates 2698367..2699689 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A483IVM3
Locus tag QDF61_RS13280 Protein ID WP_029496892.1
Coordinates 2699689..2699955 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDF61_RS13260 (2693423) 2693423..2695924 + 2502 WP_032410312.1 fimbria/pilus outer membrane usher protein -
QDF61_RS13265 (2695912) 2695912..2696916 + 1005 WP_033128455.1 fimbrial protein -
QDF61_RS13270 (2697058) 2697058..2698350 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QDF61_RS13275 (2698367) 2698367..2699689 - 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
QDF61_RS13280 (2699689) 2699689..2699955 - 267 WP_029496892.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDF61_RS13285 (2700342) 2700342..2700668 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QDF61_RS13290 (2700665) 2700665..2701165 - 501 WP_020804988.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QDF61_RS13295 (2701143) 2701143..2702522 - 1380 WP_020804975.1 nucleobase:cation symporter-2 family protein -
QDF61_RS13300 (2702868) 2702868..2704022 + 1155 WP_020804972.1 FAD-dependent urate hydroxylase HpxO -
QDF61_RS13305 (2704003) 2704003..2704926 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T278558 WP_016529318.1 NZ_CP123043:c2699689-2698367 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.33 Da        Isoelectric Point: 8.5912

>AT278558 WP_029496892.1 NZ_CP123043:c2699955-2699689 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGMVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure
AlphaFold DB A0A483IVM3

References