Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 856756..857413 Replicon chromosome
Accession NZ_CP123043
Organism Klebsiella pneumoniae strain KP161637

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QDF61_RS04330 Protein ID WP_002916310.1
Coordinates 857003..857413 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QDF61_RS04325 Protein ID WP_002916312.1
Coordinates 856756..857022 (+) Length 89 a.a.

Genomic Context


QDF61_RS04310QDF61_RS04315QDF61_RS04325QDF61_RS04330QDF61_RS04340QDF61_RS04345QDF61_RS04350QDF61_RS04300QDF61_RS04305QDF61_RS04320QDF61_RS04335
Location: 854242..854553 (312 bp)
Type: Others
Protein ID: WP_004144734.1
Location: 854717..855376 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 856756..857022 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 857003..857413 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Location: 858042..858938 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 858961..859674 (714 bp)
Type: Others
Protein ID: WP_002916301.1
Location: 859680..861413 (1734 bp)
Type: Others
Protein ID: WP_004149758.1
Location: 851912..853345 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Location: 853464..854192 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 855527..856510 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Location: 857420..857941 (522 bp)
Type: Others
Protein ID: WP_002916308.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QDF61_RS04300 (851912)851912..853345-1434WP_002916322.16-phospho-beta-glucosidase BglA-
QDF61_RS04305 (853464)853464..854192-729WP_002916321.1MurR/RpiR family transcriptional regulator-
QDF61_RS04310 (854242)854242..854553+312WP_004144734.1N(4)-acetylcytidine aminohydrolase-
QDF61_RS04315 (854717)854717..855376+660WP_002916317.1hemolysin III family protein-
QDF61_RS04320 (855527)855527..856510-984WP_002916313.1tRNA-modifying protein YgfZ-
QDF61_RS04325 (856756)856756..857022+267WP_002916312.1FAD assembly factor SdhEAntitoxin
QDF61_RS04330 (857003)857003..857413+411WP_002916310.1protein YgfXToxin
QDF61_RS04335 (857420)857420..857941-522WP_002916308.1flavodoxin FldB-
QDF61_RS04340 (858042)858042..858938+897WP_004144729.1site-specific tyrosine recombinase XerD-
QDF61_RS04345 (858961)858961..859674+714WP_002916301.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
QDF61_RS04350 (859680)859680..861413+1734WP_004149758.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T278553 WP_002916310.1 NZ_CP123043:857003-857413 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT278553 WP_002916312.1 NZ_CP123043:856756-857022 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GSW7


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References