Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5300300..5300925 Replicon chromosome
Accession NZ_CP123040
Organism Klebsiella pneumoniae strain KP160802

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QDE57_RS25715 Protein ID WP_002882817.1
Coordinates 5300300..5300683 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QDE57_RS25720 Protein ID WP_004150355.1
Coordinates 5300683..5300925 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDE57_RS25700 (5297666) 5297666..5298568 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QDE57_RS25705 (5298565) 5298565..5299200 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QDE57_RS25710 (5299197) 5299197..5300126 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QDE57_RS25715 (5300300) 5300300..5300683 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QDE57_RS25720 (5300683) 5300683..5300925 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QDE57_RS25725 (5301130) 5301130..5302047 + 918 WP_004178029.1 alpha/beta hydrolase -
QDE57_RS25730 (5302061) 5302061..5303002 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QDE57_RS25735 (5303047) 5303047..5303484 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QDE57_RS25740 (5303481) 5303481..5304341 - 861 WP_004146232.1 virulence factor BrkB family protein -
QDE57_RS25745 (5304335) 5304335..5304934 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T278549 WP_002882817.1 NZ_CP123040:c5300683-5300300 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT278549 WP_004150355.1 NZ_CP123040:c5300925-5300683 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References