Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4820605..4821121 Replicon chromosome
Accession NZ_CP123040
Organism Klebsiella pneumoniae strain KP160802

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag QDE57_RS23415 Protein ID WP_009486548.1
Coordinates 4820605..4820889 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QDE57_RS23420 Protein ID WP_002886901.1
Coordinates 4820879..4821121 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDE57_RS23390 (4816001) 4816001..4816264 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QDE57_RS23395 (4816394) 4816394..4816567 + 174 WP_004222159.1 hypothetical protein -
QDE57_RS23400 (4816570) 4816570..4817313 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QDE57_RS23405 (4817670) 4817670..4819808 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QDE57_RS23410 (4820137) 4820137..4820601 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QDE57_RS23415 (4820605) 4820605..4820889 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDE57_RS23420 (4820879) 4820879..4821121 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QDE57_RS23425 (4821199) 4821199..4823108 - 1910 Protein_4593 PRD domain-containing protein -
QDE57_RS23430 (4823131) 4823131..4824285 - 1155 WP_004178372.1 lactonase family protein -
QDE57_RS23435 (4824352) 4824352..4825092 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T278547 WP_009486548.1 NZ_CP123040:c4820889-4820605 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT278547 WP_002886901.1 NZ_CP123040:c4821121-4820879 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References