Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4713683..4714493 Replicon chromosome
Accession NZ_CP123040
Organism Klebsiella pneumoniae strain KP160802

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QDE57_RS22915 Protein ID WP_004178461.1
Coordinates 4713683..4714216 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QDE57_RS22920 Protein ID WP_002887278.1
Coordinates 4714227..4714493 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDE57_RS22910 (4712514) 4712514..4713635 + 1122 WP_033128569.1 cupin domain-containing protein -
QDE57_RS22915 (4713683) 4713683..4714216 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QDE57_RS22920 (4714227) 4714227..4714493 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QDE57_RS22925 (4714596) 4714596..4716029 - 1434 WP_020804438.1 Cu(+)/Ag(+) sensor histidine kinase -
QDE57_RS22930 (4716019) 4716019..4716702 - 684 WP_020804437.1 copper response regulator transcription factor CusR -
QDE57_RS22935 (4716874) 4716874..4718259 + 1386 WP_020804440.1 efflux transporter outer membrane subunit -
QDE57_RS22940 (4718277) 4718277..4718621 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T278546 WP_004178461.1 NZ_CP123040:c4714216-4713683 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT278546 WP_002887278.1 NZ_CP123040:c4714493-4714227 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References