Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 856756..857413 Replicon chromosome
Accession NZ_CP123040
Organism Klebsiella pneumoniae strain KP160802

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QDE57_RS04330 Protein ID WP_002916310.1
Coordinates 857003..857413 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QDE57_RS04325 Protein ID WP_002916312.1
Coordinates 856756..857022 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDE57_RS04300 (851912) 851912..853345 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QDE57_RS04305 (853464) 853464..854192 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QDE57_RS04310 (854242) 854242..854553 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QDE57_RS04315 (854717) 854717..855376 + 660 WP_002916317.1 hemolysin III family protein -
QDE57_RS04320 (855527) 855527..856510 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QDE57_RS04325 (856756) 856756..857022 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QDE57_RS04330 (857003) 857003..857413 + 411 WP_002916310.1 protein YgfX Toxin
QDE57_RS04335 (857420) 857420..857941 - 522 WP_002916308.1 flavodoxin FldB -
QDE57_RS04340 (858042) 858042..858938 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QDE57_RS04345 (858961) 858961..859674 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDE57_RS04350 (859680) 859680..861413 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T278539 WP_002916310.1 NZ_CP123040:857003-857413 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT278539 WP_002916312.1 NZ_CP123040:856756-857022 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References