Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3577451..3578069 Replicon chromosome
Accession NZ_CP123036
Organism Escherichia coli strain E22

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QEN54_RS17385 Protein ID WP_001291435.1
Coordinates 3577851..3578069 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QEN54_RS17380 Protein ID WP_000344800.1
Coordinates 3577451..3577825 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN54_RS17370 (3572540) 3572540..3573733 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN54_RS17375 (3573756) 3573756..3576905 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QEN54_RS17380 (3577451) 3577451..3577825 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QEN54_RS17385 (3577851) 3577851..3578069 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QEN54_RS17390 (3578241) 3578241..3578792 + 552 WP_000102568.1 maltose O-acetyltransferase -
QEN54_RS17395 (3578908) 3578908..3579378 + 471 WP_000136192.1 YlaC family protein -
QEN54_RS17400 (3579542) 3579542..3581092 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QEN54_RS17405 (3581134) 3581134..3581487 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QEN54_RS17415 (3581866) 3581866..3582177 + 312 WP_000409911.1 MGMT family protein -
QEN54_RS17420 (3582208) 3582208..3582780 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278529 WP_001291435.1 NZ_CP123036:3577851-3578069 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278529 WP_000344800.1 NZ_CP123036:3577451-3577825 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References