Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1344445..1345070 Replicon chromosome
Accession NZ_CP123036
Organism Escherichia coli strain E22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QEN54_RS06565 Protein ID WP_000911330.1
Coordinates 1344672..1345070 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QEN54_RS06560 Protein ID WP_000450524.1
Coordinates 1344445..1344672 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN54_RS06535 (1340248) 1340248..1340718 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QEN54_RS06540 (1340718) 1340718..1341290 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QEN54_RS06545 (1341436) 1341436..1342314 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QEN54_RS06550 (1342331) 1342331..1343365 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QEN54_RS06555 (1343578) 1343578..1344291 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QEN54_RS06560 (1344445) 1344445..1344672 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QEN54_RS06565 (1344672) 1344672..1345070 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QEN54_RS06570 (1345217) 1345217..1346080 + 864 WP_001267507.1 neutral zinc metallopeptidase -
QEN54_RS06575 (1346095) 1346095..1348110 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
QEN54_RS06580 (1348184) 1348184..1348525 + 342 Protein_1285 esterase -
QEN54_RS06585 (1348607) 1348607..1349353 - 747 WP_053906593.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T278519 WP_000911330.1 NZ_CP123036:1344672-1345070 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278519 WP_000450524.1 NZ_CP123036:1344445-1344672 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References