Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 69196..69839 Replicon plasmid p20-20P2
Accession NZ_CP123031
Organism Escherichia coli strain 20-20

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QEN57_RS24065 Protein ID WP_001044768.1
Coordinates 69423..69839 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QEN57_RS24060 Protein ID WP_001261287.1
Coordinates 69196..69426 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN57_RS24050 (64374) 64374..65507 - 1134 WP_000545983.1 DUF3800 domain-containing protein -
QEN57_RS24055 (65770) 65770..68889 - 3120 WP_023909028.1 hypothetical protein -
QEN57_RS24060 (69196) 69196..69426 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QEN57_RS24065 (69423) 69423..69839 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QEN57_RS24070 (70001) 70001..72139 - 2139 WP_000350635.1 AAA family ATPase -
QEN57_RS24075 (72604) 72604..73599 + 996 WP_000246636.1 hypothetical protein -
QEN57_RS24080 (73642) 73642..74535 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / sul1 / qacE / aadA2 / dfrA12 / blaNDM-5 / blaTEM-1B / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr - 1..84132 84132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T278510 WP_001044768.1 NZ_CP123031:69423-69839 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT278510 WP_001261287.1 NZ_CP123031:69196-69426 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References