Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3549825..3550443 Replicon chromosome
Accession NZ_CP123029
Organism Escherichia coli strain 20-20

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QEN57_RS17120 Protein ID WP_001291435.1
Coordinates 3550225..3550443 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QEN57_RS17115 Protein ID WP_000344800.1
Coordinates 3549825..3550199 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN57_RS17105 (3544914) 3544914..3546107 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN57_RS17110 (3546130) 3546130..3549279 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QEN57_RS17115 (3549825) 3549825..3550199 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QEN57_RS17120 (3550225) 3550225..3550443 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QEN57_RS17125 (3550615) 3550615..3551166 + 552 WP_000102568.1 maltose O-acetyltransferase -
QEN57_RS17130 (3551282) 3551282..3551752 + 471 WP_000136192.1 YlaC family protein -
QEN57_RS17135 (3551916) 3551916..3553466 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QEN57_RS17140 (3553508) 3553508..3553861 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QEN57_RS17150 (3554239) 3554239..3554550 + 312 WP_000409911.1 MGMT family protein -
QEN57_RS17155 (3554581) 3554581..3555153 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278502 WP_001291435.1 NZ_CP123029:3550225-3550443 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278502 WP_000344800.1 NZ_CP123029:3549825-3550199 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References