Detailed information of TA system TA027847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 589089..589608
• Replicon: chromosome
• Accession: NC_017933
• Organism: Cronobacter sakazakii ES15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ES15_RS02800
• Protein ID: WP_014728030.1
• Coordinates: 589321..589608 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ES15_RS02795
• Protein ID: WP_014728029.1
• Coordinates: 589089..589331 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ES15_RS02780	585132..586250	+	1119	WP_014728026.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
ES15_RS02785	586247..586987	+	741	WP_014728027.1	KDGP aldolase family protein	-
ES15_RS02790	587101..589011	+	1911	WP_014728028.1	BglG family transcription antiterminator	-
ES15_RS02795	589089..589331	+	243	WP_014728029.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ES15_RS02800	589321..589608	+	288	WP_014728030.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ES15_RS02805	589616..590080	-	465	WP_014728031.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
ES15_RS02810	590422..592557	-	2136	WP_014728032.1	anaerobic ribonucleoside-triphosphate reductase	-
ES15_RS02815	592854..593735	-	882	WP_014728033.1	LysR family transcriptional regulator	-
ES15_RS02820	593838..594368	+	531	WP_007897802.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-62)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10879.96 Da
• Isoelectric Point: 10.5836

>T27847 WP_014728030.1 NC_017933:589321-589608 [Cronobacter sakazakii ES15]
MIYKLVFDPRALKEWHKLGETVKAQFKKKLAHVLAAPRVKSARLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAVHRLE

Nucleotide

• Length: 288 bp

>T27847 NC_017933:589321-589608 [Cronobacter sakazakii ES15]
ATGATCTATAAACTGGTCTTTGACCCACGTGCACTGAAGGAGTGGCACAAACTGGGCGAGACCGTTAAAGCGCAATTCAA
AAAGAAGCTGGCGCACGTGCTGGCGGCTCCCAGGGTGAAATCCGCCCGGTTAAGTGGCCTGCCGGACTGCTACAAAATTA
AATTAAGAACGAGCGGTTACCGGCTGGTGTATCAGGTGCGCGATGATGCTGTCTGTGTGCTGGTCATCGCGATCGGCAAA
CGCGAAAACCTGACCGTATACCAGGGGGCCGTGCACCGTCTGGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.39 Da
• Isoelectric Point: 4.7719

>AT27847 WP_014728029.1 NC_017933:589089-589331 [Cronobacter sakazakii ES15]
MATINVRLDDKLKNEAYAVLEKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPQPGIRVELDDL

Nucleotide

• Length: 243 bp

>AT27847 NC_017933:589089-589331 [Cronobacter sakazakii ES15]
ATGGCCACAATCAACGTAAGGCTTGATGACAAGCTTAAAAATGAGGCTTATGCGGTGCTGGAAAAACTGGGTATCACACC
TACCGAAGCGGTGCGTCTGCTGTTTCAGTATGTGGCGCAAAATGGCCGTATGCCGGTCAAAACGCTAACCGTCAGCGACA
GCGAAGAGGCGCTGCTGCGTACCGTGCGGGAGCGACTGGCGGATCCGCAGCCGGGCATCAGGGTTGAGCTGGATGATCTA
TAA