Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3604771..3605389 Replicon chromosome
Accession NZ_CP123017
Organism Escherichia coli strain 19-7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QEN55_RS17530 Protein ID WP_001291435.1
Coordinates 3605171..3605389 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QEN55_RS17525 Protein ID WP_000344800.1
Coordinates 3604771..3605145 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN55_RS17515 (3599860) 3599860..3601053 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN55_RS17520 (3601076) 3601076..3604225 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QEN55_RS17525 (3604771) 3604771..3605145 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QEN55_RS17530 (3605171) 3605171..3605389 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QEN55_RS17535 (3605561) 3605561..3606112 + 552 WP_000102568.1 maltose O-acetyltransferase -
QEN55_RS17540 (3606228) 3606228..3606698 + 471 WP_000136192.1 YlaC family protein -
QEN55_RS17545 (3606862) 3606862..3608412 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QEN55_RS17550 (3608454) 3608454..3608807 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QEN55_RS17560 (3609186) 3609186..3609497 + 312 WP_000409911.1 MGMT family protein -
QEN55_RS17565 (3609528) 3609528..3610100 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278451 WP_001291435.1 NZ_CP123017:3605171-3605389 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278451 WP_000344800.1 NZ_CP123017:3604771-3605145 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References