Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 406461..407046 Replicon chromosome
Accession NC_017933
Organism Cronobacter sakazakii ES15

Toxin (Protein)


Gene name PumA Uniprot ID A0A853H7C5
Locus tag ES15_RS01940 Protein ID WP_014727945.1
Coordinates 406741..407046 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2S9UB62
Locus tag ES15_RS01935 Protein ID WP_007852536.1
Coordinates 406461..406736 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES15_RS01930 404813..406444 + 1632 WP_007891561.1 Na/Pi cotransporter family protein -
ES15_RS01935 406461..406736 - 276 WP_007852536.1 putative addiction module antidote protein Antitoxin
ES15_RS01940 406741..407046 - 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES15_RS01945 407263..407613 + 351 WP_007852532.1 type II toxin-antitoxin system RelE/ParE family toxin -
ES15_RS01950 407610..407933 + 324 WP_014727946.1 helix-turn-helix domain-containing protein -
ES15_RS01955 407964..408236 - 273 WP_007702377.1 DUF3811 domain-containing protein -
ES15_RS01960 408328..409263 - 936 WP_004387518.1 ketopantoate/pantoate/pantothenate transporter PanS -
ES15_RS01965 409425..411017 - 1593 WP_014727947.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 406461..414658 8197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11588.58 Da        Isoelectric Point: 10.3395

>T27845 WP_014727945.1 NC_017933:c407046-406741 [Cronobacter sakazakii ES15]
MKHIFQTEVFRRWQASLKDQRVKTMIAARLFRLANGLPGDVKPVGAGISELRIHYGAGYRIYFKQHGEVIVILLCGGDKH
TQDKDILLAKMLADLPENQWR

Download         Length: 306 bp

>T27845 NC_017933:c407046-406741 [Cronobacter sakazakii ES15]
ATGAAGCATATTTTTCAAACTGAAGTATTCCGCCGCTGGCAAGCCAGTCTGAAAGACCAGCGGGTAAAAACGATGATTGC
CGCGCGGCTTTTTCGGCTGGCTAATGGTTTGCCTGGTGATGTTAAGCCCGTCGGCGCAGGCATCAGTGAACTGCGTATTC
ACTACGGCGCGGGATACCGGATTTATTTCAAACAACACGGCGAGGTGATTGTCATTTTGCTTTGTGGTGGTGATAAGCAC
ACGCAGGATAAAGACATTCTTCTTGCGAAAATGCTGGCTGACCTGCCAGAGAACCAGTGGAGATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9597.06 Da        Isoelectric Point: 6.4609

>AT27845 WP_007852536.1 NC_017933:c406736-406461 [Cronobacter sakazakii ES15]
MKLTEYDPAAALVDDEEIAFFMADALETGDAGHIAKALGVVARAKGMSHIAAQTGLSREQLYRSFSDKGNPTLKTTLAVM
KALGLGLTVKS

Download         Length: 276 bp

>AT27845 NC_017933:c406736-406461 [Cronobacter sakazakii ES15]
ATGAAGCTGACCGAATACGATCCCGCAGCGGCGCTGGTAGATGATGAGGAGATCGCCTTCTTTATGGCGGACGCGCTCGA
AACTGGCGACGCCGGACATATTGCAAAGGCGCTGGGCGTCGTCGCGCGCGCTAAAGGCATGTCGCATATCGCCGCTCAGA
CAGGGCTGTCGCGTGAACAGCTGTACCGTTCTTTCAGTGATAAAGGCAACCCAACGCTTAAAACCACGCTGGCAGTGATG
AAAGCGTTGGGTCTCGGTTTAACGGTTAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853H7C5

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UB62

References