Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1349732..1350357 Replicon chromosome
Accession NZ_CP123017
Organism Escherichia coli strain 19-7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QEN55_RS06595 Protein ID WP_000911330.1
Coordinates 1349959..1350357 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QEN55_RS06590 Protein ID WP_000450524.1
Coordinates 1349732..1349959 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN55_RS06565 (1345535) 1345535..1346005 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QEN55_RS06570 (1346005) 1346005..1346577 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QEN55_RS06575 (1346723) 1346723..1347601 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QEN55_RS06580 (1347618) 1347618..1348652 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QEN55_RS06585 (1348865) 1348865..1349578 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QEN55_RS06590 (1349732) 1349732..1349959 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QEN55_RS06595 (1349959) 1349959..1350357 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QEN55_RS06600 (1350504) 1350504..1351367 + 864 WP_001267507.1 neutral zinc metallopeptidase -
QEN55_RS06605 (1351382) 1351382..1353397 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
QEN55_RS06610 (1353471) 1353471..1353812 + 342 Protein_1291 esterase -
QEN55_RS06615 (1353894) 1353894..1354640 - 747 WP_053906593.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T278441 WP_000911330.1 NZ_CP123017:1349959-1350357 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278441 WP_000450524.1 NZ_CP123017:1349732-1349959 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References