Detailed information of TA system TA027844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 212585..213051
• Replicon: chromosome
• Accession: NC_017933
• Organism: Cronobacter sakazakii ES15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ES15_RS00970
• Protein ID: WP_041460798.1
• Coordinates: 212585..212860 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ES15_RS00975
• Protein ID: WP_014727866.1
• Coordinates: 212860..213051 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ES15_RS00955	208684..209526	-	843	WP_004388308.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
ES15_RS00960	209719..211761	+	2043	WP_014727863.1	oligopeptidase A	-
ES15_RS00965	211770..212522	+	753	WP_014727864.1	16S rRNA (guanine(1516)-N(2))-methyltransferase RsmJ	-
ES15_RS00970	212585..212860	-	276	WP_041460798.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ES15_RS00975	212860..213051	-	192	WP_014727866.1	hypothetical protein	Antitoxin
ES15_RS00980	213226..213663	-	438	WP_004388310.1	universal stress protein UspA	-
ES15_RS00985	214054..214389	+	336	WP_004388311.1	universal stress protein UspB	-
ES15_RS00990	214440..215942	-	1503	WP_004388312.1	inorganic phosphate transporter PitA	-
ES15_RS00995	216172..217362	+	1191	WP_014727867.1	NAD(P)/FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10469.11 Da
• Isoelectric Point: 5.6662

>T27844 WP_041460798.1 NC_017933:c212860-212585 [Cronobacter sakazakii ES15]
ILSIRWTEEAKMDLFALISFVASDNPSAAQALLTRIEESILPAAYYPEMFREGRVPDTREIIAHPNYIVVYKVTSEYLLV
LSVLHARQRYP

Nucleotide

• Length: 276 bp

>T27844 NC_017933:c212860-212585 [Cronobacter sakazakii ES15]
ATACTCTCCATTCGATGGACTGAAGAAGCAAAAATGGATCTTTTTGCGCTTATTAGTTTTGTTGCCAGTGATAATCCTTC
CGCCGCGCAGGCGCTGTTAACGCGTATTGAAGAATCAATTTTACCCGCAGCGTACTATCCGGAGATGTTCCGCGAAGGCA
GAGTGCCAGATACGCGTGAAATCATTGCTCACCCGAATTACATCGTCGTTTATAAAGTCACTTCTGAATATCTGCTGGTG
CTGAGCGTTCTGCATGCCCGTCAGCGCTACCCCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7159.24 Da
• Isoelectric Point: 10.4757

>AT27844 WP_014727866.1 NC_017933:c213051-212860 [Cronobacter sakazakii ES15]
MPKHDSPGVSSLKTHKQAEQYELWFREKVEAAAASRQPITPHEDVMASARKIIESAKVRRKMA

Nucleotide

• Length: 192 bp

>AT27844 NC_017933:c213051-212860 [Cronobacter sakazakii ES15]
ATGCCAAAACATGACTCGCCCGGCGTCTCCAGTCTCAAGACCCATAAACAGGCGGAACAGTACGAGCTGTGGTTTCGTGA
AAAAGTGGAAGCCGCAGCGGCAAGCCGCCAGCCCATCACGCCGCATGAAGATGTGATGGCAAGCGCGCGCAAGATCATTG
AGAGCGCAAAAGTGAGGAGAAAAATGGCGTAA