Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 92910..93553 Replicon plasmid p18-4P1
Accession NZ_CP123014
Organism Escherichia coli strain 18-4

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QEN56_RS24025 Protein ID WP_001044768.1
Coordinates 93137..93553 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QEN56_RS24020 Protein ID WP_001261287.1
Coordinates 92910..93140 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN56_RS24010 (88088) 88088..89221 - 1134 WP_000545983.1 DUF3800 domain-containing protein -
QEN56_RS24015 (89484) 89484..92603 - 3120 WP_023909028.1 hypothetical protein -
QEN56_RS24020 (92910) 92910..93140 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QEN56_RS24025 (93137) 93137..93553 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QEN56_RS24030 (93715) 93715..95853 - 2139 WP_000350635.1 AAA family ATPase -
QEN56_RS24035 (96318) 96318..97313 + 996 WP_000246636.1 hypothetical protein -
QEN56_RS24040 (97356) 97356..98249 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / sul1 / qacE / aadA2 / dfrA12 / blaNDM-5 / blaTEM-1B / aac(3)-IId / mph(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr - 1..107858 107858
- flank IS/Tn - - 98386..98763 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T278432 WP_001044768.1 NZ_CP123014:93137-93553 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT278432 WP_001261287.1 NZ_CP123014:92910-93140 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References