Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4328902..4329399 Replicon chromosome
Accession NZ_CP123013
Organism Escherichia coli strain 18-4

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QEN56_RS21030 Protein ID WP_001173343.1
Coordinates 4328902..4329075 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag QEN56_RS21035 Protein ID WP_001425728.1
Coordinates 4329103..4329399 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN56_RS21020 (4325572) 4325572..4327029 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
QEN56_RS21025 (4327266) 4327266..4328783 + 1518 WP_001295074.1 lysine--tRNA ligase -
QEN56_RS21030 (4328902) 4328902..4329075 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QEN56_RS21035 (4329103) 4329103..4329399 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QEN56_RS21040 (4329626) 4329626..4329898 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QEN56_RS21045 (4329910) 4329910..4330140 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QEN56_RS21050 (4330321) 4330321..4331952 + 1632 WP_001216487.1 sensor histidine kinase -
QEN56_RS21055 (4331949) 4331949..4332668 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278426 WP_001173343.1 NZ_CP123013:c4329075-4328902 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT278426 WP_001425728.1 NZ_CP123013:c4329399-4329103 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References