Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3596858..3597476 Replicon chromosome
Accession NZ_CP123013
Organism Escherichia coli strain 18-4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QEN56_RS17490 Protein ID WP_001291435.1
Coordinates 3597258..3597476 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QEN56_RS17485 Protein ID WP_000344800.1
Coordinates 3596858..3597232 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN56_RS17475 (3591947) 3591947..3593140 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN56_RS17480 (3593163) 3593163..3596312 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QEN56_RS17485 (3596858) 3596858..3597232 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QEN56_RS17490 (3597258) 3597258..3597476 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QEN56_RS17495 (3597648) 3597648..3598199 + 552 WP_000102568.1 maltose O-acetyltransferase -
QEN56_RS17500 (3598315) 3598315..3598785 + 471 WP_000136192.1 YlaC family protein -
QEN56_RS17505 (3598949) 3598949..3600499 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QEN56_RS17510 (3600541) 3600541..3600894 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QEN56_RS17520 (3601273) 3601273..3601584 + 312 WP_000409911.1 MGMT family protein -
QEN56_RS17525 (3601615) 3601615..3602187 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278425 WP_001291435.1 NZ_CP123013:3597258-3597476 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278425 WP_000344800.1 NZ_CP123013:3596858-3597232 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References