Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 777803..778442 Replicon chromosome
Accession NC_017920
Organism Burkholderia sp. KJ006

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DRA7
Locus tag MYA_RS03525 Protein ID WP_011883463.1
Coordinates 778023..778442 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132DHM6
Locus tag MYA_RS03520 Protein ID WP_011883461.1
Coordinates 777803..778036 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYA_RS03510 774369..776732 + 2364 WP_014722530.1 xanthine dehydrogenase molybdopterin binding subunit -
MYA_RS03515 776820..777476 + 657 WP_011883460.1 xanthine dehydrogenase accessory protein XdhC -
MYA_RS03520 777803..778036 + 234 WP_011883461.1 DNA-binding protein Antitoxin
MYA_RS03525 778023..778442 + 420 WP_011883463.1 type II toxin-antitoxin system VapC family toxin Toxin
MYA_RS03530 778572..778973 + 402 WP_014722533.1 polyketide cyclase -
MYA_RS03535 779014..779958 - 945 WP_011883467.1 LysR family transcriptional regulator -
MYA_RS03540 780028..780666 - 639 WP_011883469.1 2-hydroxychromene-2-carboxylate isomerase -
MYA_RS03545 780761..782194 - 1434 WP_011883471.1 ABC transporter substrate-binding protein -
MYA_RS03550 782663..783019 + 357 WP_011883473.1 BON domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T27841 WP_011883463.1 NC_017920:778023-778442 [Burkholderia sp. KJ006]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LAVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T27841 NC_017920:778023-778442 [Burkholderia sp. KJ006]
ATGTTTTTGGTTGATACCAACGTCATCAGCGAAGTACGGAAGCGGGAGCGAGCAGATAAAGGTGTGATGGCGTTTTTCCG
CAAGGCCGCGCAGGACGATGCCGATCTGTACCTTTCCGTGGTGACGGTTGGCGAACTGCGGCGCGGTGTGGAAATCATCC
GTCACCGTGGCGACAAGTCCCAGGCGACGCGCCTTGAAAACTGGCTCGATGGCGTACTTCGGGAGTTTGCGTCGAACATT
CTGGCGGTGGACGAAGAGATCGGGCAGTTGTGGGGACGCCTGCGCGTCCCGCATCCCGAGCACTCGCTCGACAAGTTGAT
CGCGGCAACGGCGTTGATCCACGACCTGATCGTCGTGACGCGGAACGTCGATGATTTCGCCGGAACGGGCGCACGCGTTC
TGAACCCATTCGAAAGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8379.44 Da        Isoelectric Point: 5.0644

>AT27841 WP_011883461.1 NC_017920:777803-778036 [Burkholderia sp. KJ006]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Download         Length: 234 bp

>AT27841 NC_017920:777803-778036 [Burkholderia sp. KJ006]
ATGGCAACTCTTCTGGTGAGAAATGTGGACGAGGAACTCGTCCAAAGCCTGCGCGAGCGGGCCGCAGCCAACGGGCGTAG
TGCGGAGGCCGAGCATCGAGAGATCCTGGCAAAGGCGCTGCGCGCGCCGCAGCGCAAGACGTTCGCGCAGGTGTTGATGA
GTATCCCGAACGTCGGAACCGATGCCGATTTTGCGCGCGTGGATGACGGCGAGGCAGCGAATGTTTTTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DRA7

Antitoxin

Source ID Structure
AlphaFold DB A0A132DHM6

References