Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4101325..4101850 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag QEN28_RS19615 Protein ID WP_029305600.1
Coordinates 4101545..4101850 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag QEN28_RS19610 Protein ID WP_000813634.1
Coordinates 4101325..4101543 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS19595 (4096481) 4096481..4097380 + 900 WP_000963206.1 nucleotide-binding protein -
QEN28_RS19600 (4097430) 4097430..4099655 - 2226 WP_040073691.1 P-loop NTPase fold protein -
QEN28_RS19605 (4099657) 4099657..4100745 - 1089 WP_000952217.1 transcriptional repressor PifC -
QEN28_RS19610 (4101325) 4101325..4101543 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
QEN28_RS19615 (4101545) 4101545..4101850 + 306 WP_029305600.1 type II toxin-antitoxin system toxin CcdB Toxin
QEN28_RS19620 (4101851) 4101851..4102432 + 582 Protein_3859 tyrosine-type recombinase/integrase -
QEN28_RS19625 (4102408) 4102408..4102548 + 141 Protein_3860 RepB family plasmid replication initiator protein -
QEN28_RS19630 (4103136) 4103136..4104302 + 1167 WP_000772446.1 plasmid-partitioning protein SopA -
QEN28_RS19635 (4104302) 4104302..4105273 + 972 WP_000817031.1 ParB/RepB/Spo0J family plasmid partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4090602..4136494 45892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11716.55 Da        Isoelectric Point: 6.4674

>T278401 WP_029305600.1 NZ_CP123009:4101545-4101850 [Escherichia coli O155]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVPVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT278401 WP_000813634.1 NZ_CP123009:4101325-4101543 [Escherichia coli O155]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References