Detailed information of TA system TA027840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 154436..155073
• Replicon: chromosome
• Accession: NC_017920
• Organism: Burkholderia sp. KJ006

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: I2DIN1
• Locus tag: MYA_RS00650
• Protein ID: WP_014722201.1
• Coordinates: 154672..155073 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: MYA_RS00645
• Protein ID: WP_011882846.1
• Coordinates: 154436..154672 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYA_RS00630	150001..151035	+	1035	WP_011882843.1	helix-turn-helix domain-containing protein	-
MYA_RS00635	151330..152457	-	1128	WP_014722198.1	ADP-heptose--LPS heptosyltransferase	-
MYA_RS00640	152454..154157	-	1704	WP_014722199.1	thiamine pyrophosphate-binding protein	-
MYA_RS00645	154436..154672	+	237	WP_011882846.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MYA_RS00650	154672..155073	+	402	WP_014722201.1	type II toxin-antitoxin system VapC family toxin	Toxin
MYA_RS00655	155141..156529	-	1389	WP_014722202.1	L-serine ammonia-lyase	-
MYA_RS00660	156560..157696	-	1137	WP_011882849.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14908.05 Da
• Isoelectric Point: 5.1684

>T27840 WP_014722201.1 NC_017920:154672-155073 [Burkholderia sp. KJ006]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T27840 NC_017920:154672-155073 [Burkholderia sp. KJ006]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTATGCCGAGCTGGAGTACGGCGTCACCGCTTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCCGTGCGTGACGCAACGCGCGCATGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAATGACGAGCGCGATTTCACGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9021.21 Da
• Isoelectric Point: 7.2056

>AT27840 WP_011882846.1 NC_017920:154436-154672 [Burkholderia sp. KJ006]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLKKFAKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT27840 NC_017920:154436-154672 [Burkholderia sp. KJ006]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGCGCATCGGCGACGAGATTCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGCTCAAGA
AGTTCGCGAAGTTCGCGCCCGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTGTGA

Structures

Toxin

• AlphaFold DB: I2DIN1