Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3243566..3244063 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QEN28_RS15700 Protein ID WP_001173343.1
Coordinates 3243890..3244063 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QEN28_RS15695 Protein ID WP_000398619.1
Coordinates 3243566..3243862 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS15675 (3240297) 3240297..3241016 - 720 WP_000611288.1 two-component system response regulator DcuR -
QEN28_RS15680 (3241013) 3241013..3242644 - 1632 WP_001216461.1 sensor histidine kinase -
QEN28_RS15685 (3242825) 3242825..3243055 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
QEN28_RS15690 (3243067) 3243067..3243339 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QEN28_RS15695 (3243566) 3243566..3243862 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QEN28_RS15700 (3243890) 3243890..3244063 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QEN28_RS15705 (3244182) 3244182..3245699 - 1518 WP_001295074.1 lysine--tRNA ligase -
QEN28_RS15710 (3245936) 3245936..3247393 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278398 WP_001173343.1 NZ_CP123009:3243890-3244063 [Escherichia coli O155]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278398 WP_000398619.1 NZ_CP123009:3243566-3243862 [Escherichia coli O155]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References