Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2255521..2256321 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag QEN28_RS11010 Protein ID WP_136721175.1
Coordinates 2255794..2256321 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag QEN28_RS11005 Protein ID WP_001277108.1
Coordinates 2255521..2255787 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS10985 (2251179) 2251179..2251847 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QEN28_RS10990 (2251840) 2251840..2252898 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QEN28_RS10995 (2253143) 2253143..2253997 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QEN28_RS11000 (2254268) 2254268..2255371 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QEN28_RS11005 (2255521) 2255521..2255787 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QEN28_RS11010 (2255794) 2255794..2256321 + 528 WP_136721175.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QEN28_RS11015 (2256318) 2256318..2256701 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
QEN28_RS11020 (2257125) 2257125..2258234 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QEN28_RS11025 (2258282) 2258282..2259208 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QEN28_RS11030 (2259205) 2259205..2260482 + 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
QEN28_RS11035 (2260479) 2260479..2261246 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19740.77 Da        Isoelectric Point: 7.7438

>T278396 WP_136721175.1 NZ_CP123009:2255794-2256321 [Escherichia coli O155]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENEYAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT278396 WP_001277108.1 NZ_CP123009:2255521-2255787 [Escherichia coli O155]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References