Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2234228..2234814 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QEN28_RS10885 Protein ID WP_042014162.1
Coordinates 2234228..2234458 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QEN28_RS10890 Protein ID WP_000593555.1
Coordinates 2234455..2234814 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS10875 (2230265) 2230265..2233000 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
QEN28_RS10880 (2233000) 2233000..2234124 + 1125 WP_001314210.1 ABC transporter permease -
QEN28_RS10885 (2234228) 2234228..2234458 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QEN28_RS10890 (2234455) 2234455..2234814 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QEN28_RS10895 (2234934) 2234934..2235335 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QEN28_RS10900 (2235341) 2235341..2236147 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QEN28_RS10905 (2236144) 2236144..2236908 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QEN28_RS10910 (2236908) 2236908..2237741 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QEN28_RS10915 (2237738) 2237738..2238682 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T278395 WP_042014162.1 NZ_CP123009:2234228-2234458 [Escherichia coli O155]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT278395 WP_000593555.1 NZ_CP123009:2234455-2234814 [Escherichia coli O155]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References