Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1825808..1826462 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag QEN28_RS08995 Protein ID WP_000244772.1
Coordinates 1826055..1826462 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QEN28_RS08990 Protein ID WP_000354046.1
Coordinates 1825808..1826074 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS08965 (1821096) 1821096..1821839 + 744 WP_000951964.1 SDR family oxidoreductase -
QEN28_RS08970 (1821896) 1821896..1823329 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QEN28_RS08975 (1823374) 1823374..1823685 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
QEN28_RS08980 (1823849) 1823849..1824508 + 660 WP_000250274.1 hemolysin III family protein -
QEN28_RS08985 (1824585) 1824585..1825565 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QEN28_RS08990 (1825808) 1825808..1826074 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QEN28_RS08995 (1826055) 1826055..1826462 + 408 WP_000244772.1 protein YgfX Toxin
QEN28_RS09000 (1826502) 1826502..1827023 - 522 WP_001055874.1 flavodoxin FldB -
QEN28_RS09005 (1827135) 1827135..1828031 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QEN28_RS09010 (1828056) 1828056..1828766 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QEN28_RS09015 (1828772) 1828772..1830505 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T278393 WP_000244772.1 NZ_CP123009:1826055-1826462 [Escherichia coli O155]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278393 WP_000354046.1 NZ_CP123009:1825808-1826074 [Escherichia coli O155]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References