278392

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1602818..1603655 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QEN28_RS07955 Protein ID WP_000227784.1
Coordinates 1603113..1603655 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QEN28_RS07950 Protein ID WP_001297137.1
Coordinates 1602818..1603129 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS07925 (1597838) 1597838..1598785 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
QEN28_RS07930 (1598807) 1598807..1600798 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QEN28_RS07935 (1600788) 1600788..1601402 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QEN28_RS07940 (1601402) 1601402..1601731 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QEN28_RS07945 (1601743) 1601743..1602633 + 891 WP_000971336.1 heme o synthase -
QEN28_RS07950 (1602818) 1602818..1603129 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QEN28_RS07955 (1603113) 1603113..1603655 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QEN28_RS07960 (1603711) 1603711..1604646 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QEN28_RS07965 (1605054) 1605054..1606418 + 1365 WP_001000978.1 MFS transporter -
QEN28_RS07970 (1606546) 1606546..1607037 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QEN28_RS07975 (1607205) 1607205..1608116 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T278392 WP_000227784.1 NZ_CP123009:1603113-1603655 [Escherichia coli O155]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT278392 WP_001297137.1 NZ_CP123009:1602818-1603129 [Escherichia coli O155]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References