Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1568741..1569359 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QEN28_RS07785 Protein ID WP_001291435.1
Coordinates 1569141..1569359 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QEN28_RS07780 Protein ID WP_000344800.1
Coordinates 1568741..1569115 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS07770 (1563830) 1563830..1565023 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN28_RS07775 (1565046) 1565046..1568195 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QEN28_RS07780 (1568741) 1568741..1569115 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QEN28_RS07785 (1569141) 1569141..1569359 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QEN28_RS07790 (1569531) 1569531..1570082 + 552 WP_000102568.1 maltose O-acetyltransferase -
QEN28_RS07795 (1570198) 1570198..1570668 + 471 WP_000136192.1 YlaC family protein -
QEN28_RS07800 (1570832) 1570832..1572382 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QEN28_RS07805 (1572424) 1572424..1572777 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QEN28_RS07815 (1573156) 1573156..1573467 + 312 WP_000409911.1 MGMT family protein -
QEN28_RS07820 (1573498) 1573498..1574070 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278391 WP_001291435.1 NZ_CP123009:1569141-1569359 [Escherichia coli O155]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278391 WP_000344800.1 NZ_CP123009:1568741-1569115 [Escherichia coli O155]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References