Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1096237..1096875 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QEN28_RS05385 Protein ID WP_000813794.1
Coordinates 1096699..1096875 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QEN28_RS05380 Protein ID WP_136721302.1
Coordinates 1096237..1096653 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS05360 (1091389) 1091389..1092330 - 942 WP_001251319.1 ABC transporter permease -
QEN28_RS05365 (1092331) 1092331..1093344 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QEN28_RS05370 (1093362) 1093362..1094507 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QEN28_RS05375 (1094752) 1094752..1096158 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QEN28_RS05380 (1096237) 1096237..1096653 - 417 WP_136721302.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QEN28_RS05385 (1096699) 1096699..1096875 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QEN28_RS05390 (1097097) 1097097..1097327 + 231 WP_000494244.1 YncJ family protein -
QEN28_RS05395 (1097419) 1097419..1099380 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QEN28_RS05400 (1099453) 1099453..1099989 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QEN28_RS05405 (1100081) 1100081..1101256 + 1176 WP_001236319.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1101296..1102561 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T278389 WP_000813794.1 NZ_CP123009:c1096875-1096699 [Escherichia coli O155]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15245.69 Da        Isoelectric Point: 5.1738

>AT278389 WP_136721302.1 NZ_CP123009:c1096653-1096237 [Escherichia coli O155]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAKAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References