Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3855858..3856483 Replicon chromosome
Accession NZ_CP123008
Organism Escherichia coli strain NWU_4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QEN27_RS18590 Protein ID WP_000911317.1
Coordinates 3855858..3856256 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag QEN27_RS18595 Protein ID WP_000450532.1
Coordinates 3856256..3856483 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN27_RS18575 (3852184) 3852184..3852681 + 498 WP_000605859.1 entry exclusion protein -
QEN27_RS18580 (3852713) 3852713..3853444 + 732 WP_000850430.1 conjugal transfer complement resistance protein TraT -
QEN27_RS18585 (3853696) 3853696..3855849 + 2154 WP_023568632.1 type IV conjugative transfer system coupling protein TraD -
QEN27_RS18590 (3855858) 3855858..3856256 - 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
QEN27_RS18595 (3856256) 3856256..3856483 - 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T278377 WP_000911317.1 NZ_CP123008:c3856256-3855858 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT278377 WP_000450532.1 NZ_CP123008:c3856483-3856256 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References