Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2693197..2693997 Replicon chromosome
Accession NZ_CP123008
Organism Escherichia coli strain NWU_4

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag QEN27_RS13190 Protein ID WP_136721175.1
Coordinates 2693470..2693997 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag QEN27_RS13185 Protein ID WP_001277108.1
Coordinates 2693197..2693463 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN27_RS13165 (2688855) 2688855..2689523 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QEN27_RS13170 (2689516) 2689516..2690574 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QEN27_RS13175 (2690819) 2690819..2691673 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QEN27_RS13180 (2691944) 2691944..2693047 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QEN27_RS13185 (2693197) 2693197..2693463 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QEN27_RS13190 (2693470) 2693470..2693997 + 528 WP_136721175.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QEN27_RS13195 (2693994) 2693994..2694377 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
QEN27_RS13200 (2694801) 2694801..2695910 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QEN27_RS13205 (2695958) 2695958..2696884 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QEN27_RS13210 (2696881) 2696881..2698158 + 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
QEN27_RS13215 (2698155) 2698155..2698922 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19740.77 Da        Isoelectric Point: 7.7438

>T278371 WP_136721175.1 NZ_CP123008:2693470-2693997 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENEYAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT278371 WP_001277108.1 NZ_CP123008:2693197-2693463 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References