Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5852080..5853788 Replicon chromosome
Accession NC_017911
Organism Pseudomonas fluorescens A506

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PFLA506_RS26420 Protein ID WP_014720526.1
Coordinates 5852080..5852958 (+) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PFLA506_RS26425 Protein ID WP_003195671.1
Coordinates 5852955..5853788 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLA506_RS26395 5848071..5848922 + 852 WP_003195659.1 ABC transporter ATP-binding protein -
PFLA506_RS26400 5848962..5849954 + 993 WP_014720522.1 ABC transporter substrate-binding protein -
PFLA506_RS26405 5849982..5850758 + 777 WP_014720523.1 ABC transporter permease -
PFLA506_RS26410 5850758..5851522 + 765 WP_044483644.1 SDR family oxidoreductase -
PFLA506_RS26415 5851536..5852075 + 540 WP_014720525.1 cupin domain-containing protein -
PFLA506_RS26420 5852080..5852958 + 879 WP_014720526.1 alpha/beta hydrolase Toxin
PFLA506_RS26425 5852955..5853788 + 834 WP_003195671.1 IclR family transcriptional regulator Antitoxin
PFLA506_RS26430 5853790..5854587 + 798 WP_014720527.1 SDR family oxidoreductase -
PFLA506_RS26435 5854580..5856265 + 1686 WP_044483532.1 thiamine pyrophosphate-binding protein -
PFLA506_RS26440 5856276..5857088 + 813 WP_014720529.1 aspartate dehydrogenase -
PFLA506_RS26445 5857098..5858594 + 1497 WP_014720530.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(45-276)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30890.34 Da        Isoelectric Point: 7.6898

>T27837 WP_014720526.1 NC_017911:5852080-5852958 [Pseudomonas fluorescens A506]
MLPGLSQAAPTADLQAQLERDFPQRLVAAAGGQQALRECGAGPVVVLLHGIGSGAASWLQVARQLATQARVIAWDAPGYG
DSSALESDVPKAEQYAARLAQMLDALEVETFVLVGHSLGALTALAFARSSQAHRVSRLVLISPARGYGAPQLAQRRQQVR
QQRLDNLQRLGIAGLAEQRSAHMLSPRATPQALAWVRWNMARLNPVGYRQAIELLCGDDLLRHGQPAMPCEVHCGEADSI
TPAEACLSVAKALGASFNLIADAGHASPIEQPQVVAGRLACALQQSLTGTTL

Download         Length: 879 bp

>T27837 NC_017911:5852080-5852958 [Pseudomonas fluorescens A506]
ATGCTGCCAGGACTTTCTCAAGCCGCGCCGACGGCCGACCTGCAAGCCCAACTGGAGCGTGATTTTCCTCAGCGCCTGGT
GGCTGCAGCCGGAGGGCAACAGGCCTTGCGCGAATGCGGCGCGGGGCCAGTGGTGGTGTTGCTGCACGGTATCGGCTCCG
GAGCGGCGTCCTGGCTGCAAGTGGCTCGGCAACTGGCAACCCAGGCCCGGGTCATTGCGTGGGATGCACCCGGCTACGGC
GACTCCAGTGCACTGGAGTCGGACGTTCCCAAGGCTGAGCAGTACGCAGCACGTTTGGCACAGATGCTCGATGCATTGGA
GGTCGAAACCTTCGTGCTGGTGGGTCACTCACTGGGAGCCCTCACCGCCCTGGCGTTCGCCCGCAGTTCGCAGGCCCATC
GGGTGAGCCGCCTGGTGTTGATCAGCCCGGCTCGCGGTTATGGCGCACCGCAGCTGGCCCAACGGCGCCAACAGGTACGC
CAGCAGCGCCTGGACAACCTGCAACGTCTGGGTATCGCCGGCCTGGCCGAACAACGCAGCGCTCACATGTTGTCGCCGCG
TGCCACGCCCCAGGCCCTGGCCTGGGTGCGTTGGAACATGGCACGCCTGAACCCCGTCGGTTATCGCCAGGCGATTGAAT
TGCTGTGCGGCGATGACCTGCTGCGCCATGGCCAGCCGGCCATGCCCTGCGAGGTGCATTGCGGTGAAGCCGACAGCATC
ACCCCCGCCGAGGCCTGCCTGAGCGTGGCCAAGGCGCTGGGCGCCAGCTTCAACCTGATCGCCGACGCCGGCCACGCCAG
CCCCATCGAACAACCCCAAGTGGTTGCCGGGCGCCTGGCCTGTGCCCTCCAACAATCCCTGACAGGTACAACCCTATGA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30601.10 Da        Isoelectric Point: 6.9636

>AT27837 WP_003195671.1 NC_017911:5852955-5853788 [Pseudomonas fluorescens A506]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRVNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVMALFDLVQADRQRGFVSGEGFFESAISTVAAPVRDQSGGIVAALGVTIPTAQIGHVNF
EELLNQVRRSADELSRLLNYNGGAHNGQPRVTALMRD

Download         Length: 834 bp

>AT27837 NC_017911:5852955-5853788 [Pseudomonas fluorescens A506]
ATGAACGATTCCGATCTGCTCAAAGACGCTCAGGACAAATACATCGTTCCCGGCCTTGAGCGCGGCCTGCTATTGCTCTG
TGAGTTCAGCCGGCGCAACCGCACCCTGACCGCACCGGAGCTGGCACGCCGCCTGGCACTGCCGCGCTCGACCATCTTCC
GCCTGCTGACCACCCTGGAGACCATGGGCTTCGTCACCCGCAGCGGTAATGAATATCGTCTCGGCATGTCCGTGCTGCGC
CTGGGTTTCGAGTACCTGGCGTCGCTGGAGCTGACCGAGCTTGGCCAGCCGCTGCTGGCGCGCTTGTGCGACCGGGTCAA
CTACCCGAGCAACCTGGTGGTGCGGGACGGTCGCTCGATTGTCTACGTGGCCAAGGTTTCACCGCCTTCGGTGTTCTCCA
ACGCGGTCAACGTCGGCACCCGCCTGCCCGCCCATGCCACCGTGCTGGGGCGCATCCTGCTCGAAGACCTGTCGCTGGCC
GAATTGCGTGAGTTGTACCCCGAAGAGCACCTGGAACAACACTCACCTTGCACGCCAAAAACCGTGATGGCGCTGTTCGA
CCTGGTCCAGGCCGACCGCCAGCGCGGCTTTGTCAGTGGCGAAGGCTTTTTTGAATCGGCGATTTCCACGGTGGCCGCGC
CGGTGCGTGACCAGAGCGGCGGCATCGTCGCGGCTCTGGGCGTGACCATCCCCACGGCGCAGATCGGCCACGTCAATTTT
GAAGAACTCTTGAATCAGGTCCGGCGCAGCGCCGACGAGCTGTCACGCCTGCTCAACTACAACGGCGGCGCCCATAACGG
GCAGCCTCGCGTCACTGCCTTGATGAGAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References