Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1568692..1569310 Replicon chromosome
Accession NZ_CP123008
Organism Escherichia coli strain NWU_4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QEN27_RS07795 Protein ID WP_001291435.1
Coordinates 1569092..1569310 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QEN27_RS07790 Protein ID WP_000344800.1
Coordinates 1568692..1569066 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN27_RS07780 (1563781) 1563781..1564974 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEN27_RS07785 (1564997) 1564997..1568146 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QEN27_RS07790 (1568692) 1568692..1569066 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QEN27_RS07795 (1569092) 1569092..1569310 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QEN27_RS07800 (1569482) 1569482..1570033 + 552 WP_000102568.1 maltose O-acetyltransferase -
QEN27_RS07805 (1570149) 1570149..1570619 + 471 WP_000136192.1 YlaC family protein -
QEN27_RS07810 (1570783) 1570783..1572333 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QEN27_RS07815 (1572375) 1572375..1572728 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QEN27_RS07825 (1573107) 1573107..1573418 + 312 WP_000409911.1 MGMT family protein -
QEN27_RS07830 (1573449) 1573449..1574021 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278365 WP_001291435.1 NZ_CP123008:1569092-1569310 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278365 WP_000344800.1 NZ_CP123008:1568692-1569066 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References