Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1467511..1468149 Replicon chromosome
Accession NZ_CP123008
Organism Escherichia coli strain NWU_4

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QEN27_RS07300 Protein ID WP_000813794.1
Coordinates 1467511..1467687 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QEN27_RS07305 Protein ID WP_136721302.1
Coordinates 1467733..1468149 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN27_RS07280 (1463130) 1463130..1464305 - 1176 WP_001236319.1 BenE family transporter YdcO -
QEN27_RS07285 (1464397) 1464397..1464933 + 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QEN27_RS07290 (1465006) 1465006..1466967 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QEN27_RS07295 (1467059) 1467059..1467289 - 231 WP_000494244.1 YncJ family protein -
QEN27_RS07300 (1467511) 1467511..1467687 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QEN27_RS07305 (1467733) 1467733..1468149 + 417 WP_136721302.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QEN27_RS07310 (1468228) 1468228..1469634 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QEN27_RS07315 (1469879) 1469879..1471024 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QEN27_RS07320 (1471042) 1471042..1472055 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QEN27_RS07325 (1472056) 1472056..1472997 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1461825..1463090 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T278364 WP_000813794.1 NZ_CP123008:1467511-1467687 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15245.69 Da        Isoelectric Point: 5.1738

>AT278364 WP_136721302.1 NZ_CP123008:1467733-1468149 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAKAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References