Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 947771..948396 Replicon chromosome
Accession NZ_CP123008
Organism Escherichia coli strain NWU_4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QEN27_RS04690 Protein ID WP_000911330.1
Coordinates 947771..948169 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QEN27_RS04695 Protein ID WP_000450524.1
Coordinates 948169..948396 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN27_RS04670 (943649) 943649..943849 + 201 WP_000383836.1 YpfN family protein -
QEN27_RS04675 (943959) 943959..944657 - 699 WP_000679823.1 esterase -
QEN27_RS04680 (944731) 944731..946746 - 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QEN27_RS04685 (946761) 946761..947624 - 864 WP_001267508.1 neutral zinc metallopeptidase -
QEN27_RS04690 (947771) 947771..948169 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QEN27_RS04695 (948169) 948169..948396 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QEN27_RS04700 (948550) 948550..949263 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QEN27_RS04705 (949476) 949476..950510 - 1035 WP_136721100.1 outer membrane protein assembly factor BamC -
QEN27_RS04710 (950527) 950527..951405 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QEN27_RS04715 (951551) 951551..952123 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QEN27_RS04720 (952123) 952123..952593 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T278355 WP_000911330.1 NZ_CP123008:c948169-947771 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278355 WP_000450524.1 NZ_CP123008:c948396-948169 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References