Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-Xre |
| Location | 748928..749860 | Replicon | plasmid pSme442-SymB |
| Accession | NZ_CP123006 | ||
| Organism | Sinorhizobium meliloti strain BIM B-442D | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | F7XGP1 |
| Locus tag | QC756_RS30820 | Protein ID | WP_014530511.1 |
| Coordinates | 749306..749860 (+) | Length | 185 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | F7XGP2 |
| Locus tag | QC756_RS30815 | Protein ID | WP_014530512.1 |
| Coordinates | 748928..749299 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QC756_RS30795 (QC756_30795) | 744815..745198 | + | 384 | WP_010975573.1 | RidA family protein | - |
| QC756_RS30800 (QC756_30800) | 745215..747203 | + | 1989 | WP_014530515.1 | acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha | - |
| QC756_RS30805 (QC756_30805) | 747200..748069 | + | 870 | WP_014530514.1 | hydroxymethylglutaryl-CoA lyase | - |
| QC756_RS30810 (QC756_30810) | 748066..748851 | + | 786 | WP_014530513.1 | crotonase/enoyl-CoA hydratase family protein | - |
| QC756_RS30815 (QC756_30815) | 748928..749299 | + | 372 | WP_014530512.1 | DUF2384 domain-containing protein | Antitoxin |
| QC756_RS30820 (QC756_30820) | 749306..749860 | + | 555 | WP_014530511.1 | RES family NAD+ phosphorylase | Toxin |
| QC756_RS30825 (QC756_30825) | 749996..751366 | - | 1371 | WP_015008367.1 | FAD-binding oxidoreductase | - |
| QC756_RS30830 (QC756_30830) | 751478..752584 | - | 1107 | WP_013850797.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
| QC756_RS30835 (QC756_30835) | 752600..753475 | - | 876 | WP_013850796.1 | sulfate ABC transporter permease subunit CysW | - |
| QC756_RS30840 (QC756_30840) | 753465..754331 | - | 867 | WP_015008365.1 | sulfate ABC transporter permease subunit CysT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | htpB | 1..1662188 | 1662188 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 185 a.a. Molecular weight: 20449.31 Da Isoelectric Point: 6.4901
>T278348 WP_014530511.1 NZ_CP123006:749306-749860 [Sinorhizobium meliloti]
MRKHIPPASRPDSEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
MRKHIPPASRPDSEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
Download Length: 555 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13117.25 Da Isoelectric Point: 9.6233
>AT278348 WP_014530512.1 NZ_CP123006:748928-749299 [Sinorhizobium meliloti]
MMAVDFQIAAARFGDDHSPFLSARLVADWLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
MMAVDFQIAAARFGDDHSPFLSARLVADWLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A222K2B4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A222K374 |