278346

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1443511..1444091 Replicon plasmid pSme442-SymA
Accession NZ_CP123005
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name vapC Uniprot ID Q92XP1
Locus tag QC756_RS26595 Protein ID WP_010968151.1
Coordinates 1443708..1444091 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QC756_RS26590 Protein ID WP_088199999.1
Coordinates 1443511..1443711 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS26565 (QC756_26565) 1440480..1440644 - 165 WP_234705952.1 acyl-CoA dehydrogenase -
QC756_RS26570 (QC756_26570) 1440720..1441448 - 729 WP_014531163.1 class I SAM-dependent methyltransferase -
QC756_RS26575 (QC756_26575) 1441487..1441756 - 270 WP_127725696.1 DUF1127 domain-containing protein -
QC756_RS26580 (QC756_26580) 1441906..1442742 + 837 WP_014531162.1 helix-turn-helix transcriptional regulator -
QC756_RS26585 (QC756_26585) 1442819..1443220 - 402 WP_014531161.1 GFA family protein -
QC756_RS26590 (QC756_26590) 1443511..1443711 + 201 WP_088199999.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QC756_RS26595 (QC756_26595) 1443708..1444091 + 384 WP_010968151.1 type II toxin-antitoxin system VapC family toxin Toxin
QC756_RS26600 (QC756_26600) 1444363..1444665 - 303 WP_003526036.1 hypothetical protein -
QC756_RS26605 (QC756_26605) 1444685..1446919 - 2235 WP_017268957.1 prolyl oligopeptidase family serine peptidase -
QC756_RS26610 (QC756_26610) 1447916..1448851 + 936 WP_014989617.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1592319 1592319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14292.54 Da        Isoelectric Point: 6.9172

>T278346 WP_010968151.1 NZ_CP123005:1443708-1444091 [Sinorhizobium meliloti]
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN

Download         Length: 384 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7080.22 Da        Isoelectric Point: 11.1107

>AT278346 WP_088199999.1 NZ_CP123005:1443511-1443711 [Sinorhizobium meliloti]
MRSTINLDDTLMERAKALTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92XP1

Antitoxin

Source ID Structure

References