278345

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1400775..1401373 Replicon plasmid pSme442-SymA
Accession NZ_CP123005
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name relE Uniprot ID Q930F0
Locus tag QC756_RS26330 Protein ID WP_010967243.1
Coordinates 1400775..1401068 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q930F1
Locus tag QC756_RS26335 Protein ID WP_010967242.1
Coordinates 1401065..1401373 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS26310 (QC756_26310) 1396451..1397383 - 933 WP_014531928.1 VOC family protein -
QC756_RS26315 (QC756_26315) 1397495..1398394 + 900 WP_010967198.1 LysR family transcriptional regulator -
QC756_RS26320 (QC756_26320) 1398812..1399069 - 258 WP_080567622.1 hypothetical protein -
QC756_RS26325 (QC756_26325) 1399343..1400542 + 1200 WP_164828840.1 NAD-dependent formate dehydrogenase -
QC756_RS26330 (QC756_26330) 1400775..1401068 - 294 WP_010967243.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
QC756_RS26335 (QC756_26335) 1401065..1401373 - 309 WP_010967242.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QC756_RS26340 (QC756_26340) 1401718..1401930 + 213 WP_013845891.1 hypothetical protein -
QC756_RS26345 (QC756_26345) 1402082..1402309 - 228 WP_234705589.1 EAL domain-containing protein -
QC756_RS26350 (QC756_26350) 1402446..1403336 - 891 WP_017269181.1 hypothetical protein -
QC756_RS26355 (QC756_26355) 1403388..1405172 - 1785 WP_095918731.1 polysaccharide biosynthesis/export family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1592319 1592319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-53)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11278.93 Da        Isoelectric Point: 6.4734

>T278345 WP_010967243.1 NZ_CP123005:c1401068-1400775 [Sinorhizobium meliloti]
MRLVWARYALDDRDTIFSYIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Download         Length: 294 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11210.58 Da        Isoelectric Point: 5.6604

>AT278345 WP_010967242.1 NZ_CP123005:c1401373-1401065 [Sinorhizobium meliloti]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAALRKAAAGDR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q930F0

Antitoxin

Source ID Structure
AlphaFold DB Q930F1

References