Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1157228..1157835 Replicon plasmid pSme442-SymA
Accession NZ_CP123005
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QC756_RS25065 Protein ID WP_017264738.1
Coordinates 1157228..1157482 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QC756_RS25070 Protein ID WP_040120685.1
Coordinates 1157479..1157835 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS25035 (QC756_25035) 1152629..1153333 - 705 WP_014527995.1 haloacid dehalogenase type II -
QC756_RS25040 (QC756_25040) 1153424..1154296 + 873 WP_010968043.1 LysR family transcriptional regulator -
QC756_RS25045 (QC756_25045) 1154347..1154502 - 156 WP_153320124.1 hypothetical protein -
QC756_RS25050 (QC756_25050) 1154588..1154746 - 159 WP_017276730.1 hypothetical protein -
QC756_RS25055 (QC756_25055) 1154870..1155910 - 1041 WP_040120687.1 NAD(P)H-binding protein -
QC756_RS25060 (QC756_25060) 1155999..1156886 + 888 WP_040120686.1 LysR family transcriptional regulator -
QC756_RS25065 (QC756_25065) 1157228..1157482 + 255 WP_017264738.1 type II toxin-antitoxin system HicA family toxin Toxin
QC756_RS25070 (QC756_25070) 1157479..1157835 + 357 WP_040120685.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QC756_RS25075 (QC756_25075) 1158207..1158863 - 657 WP_010968046.1 SGNH/GDSL hydrolase family protein -
QC756_RS25080 (QC756_25080) 1158893..1159843 - 951 WP_010968047.1 ABC transporter permease -
QC756_RS25085 (QC756_25085) 1159846..1160817 - 972 WP_040120683.1 ABC transporter permease -
QC756_RS25090 (QC756_25090) 1160834..1162327 - 1494 WP_010968049.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1592319 1592319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9294.62 Da        Isoelectric Point: 9.8124

>T278343 WP_017264738.1 NZ_CP123005:1157228-1157482 [Sinorhizobium meliloti]
MNSKQRKTLAAVFKDPASGTIEWAAIENLLVAAGADVIEGNGSRVKFEKDGIIASFHRPHPDKEAKRYQVRDAREFLMQI
GVTP

Download         Length: 255 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13178.82 Da        Isoelectric Point: 5.2288

>AT278343 WP_040120685.1 NZ_CP123005:1157479-1157835 [Sinorhizobium meliloti]
MNTMTYNGYHARIEFDAEDEVFFGKIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAAGHFAEARLSA

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References