Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 556416..557101 Replicon plasmid pSme442-SymA
Accession NZ_CP123005
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QC756_RS22125 Protein ID WP_010967510.1
Coordinates 556416..556835 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QC756_RS22130 Protein ID WP_041169972.1
Coordinates 556832..557101 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS22105 (QC756_22105) 551623..552327 + 705 WP_014528617.1 autoinducer binding domain-containing protein -
QC756_RS22110 (QC756_22110) 552351..553004 - 654 Protein_530 ISNCY family transposase -
QC756_RS22115 (QC756_22115) 553396..554769 - 1374 WP_014528618.1 ISNCY family transposase -
QC756_RS22120 (QC756_22120) 554895..555895 - 1001 Protein_532 IS30 family transposase -
QC756_RS22125 (QC756_22125) 556416..556835 - 420 WP_010967510.1 type II toxin-antitoxin system VapC family toxin Toxin
QC756_RS22130 (QC756_22130) 556832..557101 - 270 WP_041169972.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QC756_RS22135 (QC756_22135) 557237..557410 + 174 Protein_535 LysR substrate-binding domain-containing protein -
QC756_RS22140 (QC756_22140) 557476..558351 - 876 WP_015445434.1 LysR family transcriptional regulator -
QC756_RS22145 (QC756_22145) 559361..559531 + 171 WP_162471696.1 hypothetical protein -
QC756_RS22150 (QC756_22150) 560107..560238 + 132 WP_267901517.1 hypothetical protein -
QC756_RS22155 (QC756_22155) 560295..560675 - 381 WP_010967516.1 transcriptional regulator -
QC756_RS22160 (QC756_22160) 560693..561004 - 312 WP_003526630.1 type II toxin-antitoxin system HigB family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1592319 1592319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14785.05 Da        Isoelectric Point: 4.8837

>T278341 WP_010967510.1 NZ_CP123005:c556835-556416 [Sinorhizobium meliloti]
VSRLYMLDTNIVSELARNPQGAVTKRIAEVGPEAVCVSIITAAELRYGCAKKGSPKLLAQIEAILGSMQVLALDVPADAE
YGNIRAELETAGKPIGPNDLFIAAHACVLGAVLVTVNSSEFTRVRDLKVENWLDFTSSG

Download         Length: 420 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10129.55 Da        Isoelectric Point: 4.4596

>AT278341 WP_041169972.1 NZ_CP123005:c557101-556832 [Sinorhizobium meliloti]
MPQLRHDEPPPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPGKDVDL

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References