278340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 198807..199342 Replicon plasmid pSme442-208
Accession NZ_CP123004
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QC756_RS19420 Protein ID WP_127515273.1
Coordinates 198807..199082 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2N8JT21
Locus tag QC756_RS19425 Protein ID WP_013845222.1
Coordinates 199082..199342 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS19395 (QC756_19395) 195130..195457 + 328 Protein_214 aldehyde dehydrogenase family protein -
QC756_RS19400 (QC756_19400) 195567..196644 + 1078 Protein_215 ISAs1-like element ISRm21 family transposase -
QC756_RS19405 (QC756_19405) 196727..196956 - 230 Protein_216 hypothetical protein -
QC756_RS19410 (QC756_19410) 197347..198456 + 1110 WP_127515277.1 ionic transporter y4hA -
QC756_RS19415 (QC756_19415) 198510..198578 - 69 Protein_218 YecA family protein -
QC756_RS19420 (QC756_19420) 198807..199082 - 276 WP_127515273.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QC756_RS19425 (QC756_19425) 199082..199342 - 261 WP_013845222.1 ribbon-helix-helix domain-containing protein Antitoxin
QC756_RS19430 (QC756_19430) 199926..200018 - 93 Protein_221 cytochrome c biogenesis protein CcdA -
QC756_RS19435 (QC756_19435) 200243..200578 + 336 Protein_222 DUF305 domain-containing protein -
QC756_RS19440 (QC756_19440) 200631..202427 + 1797 Protein_223 AAA family ATPase -
QC756_RS19445 (QC756_19445) 202436..204258 + 1823 Protein_224 ATP-dependent helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..208285 208285
- flank IS/Tn - - 195577..196644 1067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10840.42 Da        Isoelectric Point: 9.9707

>T278340 WP_127515273.1 NZ_CP123004:c199082-198807 [Sinorhizobium meliloti]
MKLEWTSKAVADLGRLYDFLASVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFDPREVRRILIGHYEIRYEIRQSTIY
VLRLWHTREER

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9652.01 Da        Isoelectric Point: 4.8182

>AT278340 WP_013845222.1 NZ_CP123004:c199342-199082 [Sinorhizobium meliloti]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDAGRVIDHQAVQAWADSLDSDK
PLSLPL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8JT21

References