Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4513040..4513680 Replicon chromosome
Accession NC_017911
Organism Pseudomonas fluorescens A506

Toxin (Protein)


Gene name vagD Uniprot ID A0A0W0MYI4
Locus tag PFLA506_RS20150 Protein ID WP_014719602.1
Coordinates 4513040..4513453 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0W0MYL2
Locus tag PFLA506_RS20155 Protein ID WP_014719603.1
Coordinates 4513450..4513680 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLA506_RS20135 4508797..4509582 - 786 WP_014719600.1 ABC transporter substrate-binding protein -
PFLA506_RS20140 4510279..4512234 - 1956 WP_005790645.1 acetate--CoA ligase -
PFLA506_RS20145 4512633..4512902 + 270 WP_014719601.1 DUF2790 domain-containing protein -
PFLA506_RS20150 4513040..4513453 - 414 WP_014719602.1 type II toxin-antitoxin system VapC family toxin Toxin
PFLA506_RS20155 4513450..4513680 - 231 WP_014719603.1 virulence factor Antitoxin
PFLA506_RS20160 4514161..4515411 + 1251 WP_014719604.1 ribonucleotide-diphosphate reductase subunit beta -
PFLA506_RS27910 4515478..4515651 + 174 Protein_4003 HNH endonuclease -
PFLA506_RS20165 4515724..4516371 + 648 WP_019819275.1 HAD-IB family hydrolase -
PFLA506_RS20170 4516463..4517422 - 960 WP_014719606.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15188.53 Da        Isoelectric Point: 7.6998

>T27834 WP_014719602.1 NC_017911:c4513453-4513040 [Pseudomonas fluorescens A506]
VTTYMLDTCICSFIMRERPECVLKRLALEVARSNRIVISAITYAEMRYGQIGKKASSKHKTLVDEFVKRLDEVLPWGVAA
VDATVEVKRSLTEQGAIIGQNDTAIAGHAIASGCTLVTNNIREFSRVAGLSYEDWVH

Download         Length: 414 bp

>T27834 NC_017911:c4513453-4513040 [Pseudomonas fluorescens A506]
GTGACGACATACATGCTGGATACCTGCATTTGCTCGTTCATCATGCGTGAGCGGCCCGAGTGCGTGCTTAAGCGTCTGGC
CTTGGAGGTGGCGAGGAGCAATCGAATCGTGATTTCGGCCATAACCTATGCCGAAATGCGATATGGACAGATTGGGAAAA
AGGCATCGTCCAAACACAAGACGTTAGTCGATGAGTTTGTGAAGCGACTCGATGAAGTGTTGCCGTGGGGCGTGGCGGCG
GTGGACGCGACGGTTGAGGTGAAGCGAAGCCTGACCGAGCAAGGGGCGATCATCGGCCAAAATGATACTGCTATTGCAGG
GCATGCAATTGCTTCGGGGTGTACGTTGGTGACCAACAATATTCGGGAGTTCAGTCGCGTAGCGGGGTTGTCTTACGAGG
ATTGGGTCCATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8654.65 Da        Isoelectric Point: 4.5557

>AT27834 WP_014719603.1 NC_017911:c4513680-4513450 [Pseudomonas fluorescens A506]
MRTVSIFKNGKNQAIRFPNDMAYEGVGELEITRNGDTITLRPVRPSWGSLSELPRADEDFLQERQDVVGDEGRFNL

Download         Length: 231 bp

>AT27834 NC_017911:c4513680-4513450 [Pseudomonas fluorescens A506]
ATGCGCACAGTCTCAATTTTTAAAAATGGAAAGAACCAGGCTATTCGATTTCCAAACGACATGGCCTATGAGGGAGTCGG
TGAGCTCGAAATCACCCGCAATGGAGATACGATTACATTACGACCTGTCCGACCTAGCTGGGGGTCGCTGAGTGAGTTAC
CCAGGGCGGACGAAGATTTTCTTCAGGAGCGTCAGGACGTTGTTGGCGATGAAGGCAGGTTCAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0MYI4

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0MYL2

References