278339

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3743121..3743782 Replicon chromosome
Accession NZ_CP123003
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name vapC Uniprot ID Q92KY5
Locus tag QC756_RS18180 Protein ID WP_010970565.1
Coordinates 3743121..3743525 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92KY4
Locus tag QC756_RS18185 Protein ID WP_010970566.1
Coordinates 3743522..3743782 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS18165 (QC756_18165) 3738664..3739776 + 1113 WP_003535893.1 3-isopropylmalate dehydrogenase -
QC756_RS18170 (QC756_18170) 3739905..3740612 + 708 WP_010970563.1 phosphatase PAP2 family protein -
QC756_RS18175 (QC756_18175) 3740713..3742602 - 1890 WP_010970564.1 MFS transporter -
QC756_RS18180 (QC756_18180) 3743121..3743525 - 405 WP_010970565.1 type II toxin-antitoxin system VapC family toxin Toxin
QC756_RS18185 (QC756_18185) 3743522..3743782 - 261 WP_010970566.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QC756_RS18190 (QC756_18190) 3743911..3744081 + 171 WP_010970567.1 hypothetical protein -
QC756_RS18195 (QC756_18195) 3744195..3745229 + 1035 WP_003531790.1 aspartate-semialdehyde dehydrogenase -
QC756_RS18200 (QC756_18200) 3745402..3746223 + 822 WP_010970568.1 lytic transglycosylase domain-containing protein -
QC756_RS18205 (QC756_18205) 3746570..3747253 - 684 WP_010970569.1 carbonic anhydrase -
QC756_RS18210 (QC756_18210) 3747427..3748308 - 882 WP_010970570.1 pyridoxal kinase PdxY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(8-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14507.71 Da        Isoelectric Point: 6.7257

>T278339 WP_010970565.1 NZ_CP123003:c3743525-3743121 [Sinorhizobium meliloti]
VISHILDTNAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL

Download         Length: 405 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9903.16 Da        Isoelectric Point: 5.1253

>AT278339 WP_010970566.1 NZ_CP123003:c3743782-3743522 [Sinorhizobium meliloti]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRSE
LDAVFR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92KY5

Antitoxin

Source ID Structure
AlphaFold DB Q92KY4

References