Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3051914..3052680 Replicon chromosome
Accession NZ_CP123003
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name tacT Uniprot ID H0G6D3
Locus tag QC756_RS15015 Protein ID WP_003533488.1
Coordinates 3052198..3052680 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag QC756_RS15010 Protein ID WP_280097403.1
Coordinates 3051914..3052198 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS14995 (QC756_14995) 3047384..3048772 + 1389 WP_003533497.1 lipopolysaccharide biosynthesis protein -
QC756_RS15000 (QC756_15000) 3048776..3050047 + 1272 WP_010970087.1 GNAT family N-acetyltransferase -
QC756_RS15005 (QC756_15005) 3050063..3051709 - 1647 WP_010970088.1 AMP-binding protein -
QC756_RS15010 (QC756_15010) 3051914..3052198 + 285 WP_280097403.1 DUF1778 domain-containing protein Antitoxin
QC756_RS15015 (QC756_15015) 3052198..3052680 + 483 WP_003533488.1 GNAT family N-acetyltransferase Toxin
QC756_RS15025 (QC756_15025) 3053145..3053654 + 510 WP_013844819.1 disulfide bond formation protein B -
QC756_RS15030 (QC756_15030) 3053686..3054243 - 558 WP_003533486.1 HNH endonuclease -
QC756_RS15035 (QC756_15035) 3054349..3054996 - 648 WP_280097404.1 DNA-3-methyladenine glycosylase -
QC756_RS15040 (QC756_15040) 3055149..3056045 + 897 WP_010970092.1 tRNA glutamyl-Q(34) synthetase GluQRS -
QC756_RS15045 (QC756_15045) 3056064..3056939 - 876 WP_010970093.1 YihY/virulence factor BrkB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-142)

Antitoxin

Vibrio phage ICP1, Orf50

(1-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17463.88 Da        Isoelectric Point: 7.3827

>T278337 WP_003533488.1 NZ_CP123003:3052198-3052680 [Sinorhizobium meliloti]
MLSAPTPLGEAHDFDLFQSGNDTLDDWLRRRAHANQASGASRTYVIAEEWRVVGYYCLASGALDLADAPSSVRRNMPDPI
PMAVLGRLAIDRDWQGKGLGAALLQDAVLRSSQAADIMGIRGLLVHAISGEAKAFYEHYGFQCSPNHPMTLVLSLKGKRR

Download         Length: 483 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10790.17 Da        Isoelectric Point: 8.5251

>AT278337 WP_280097403.1 NZ_CP123003:3051914-3052198 [Sinorhizobium meliloti]
MATKSSTDTHAKPVNLRIREDIRKVIDRAASIRGKTRSDFMIDAAYRAAEDTLLDQTLVRVDEHSYRRYLDILDQPPSGD
GFERLMNAPKPWQS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G6D3

Antitoxin

Source ID Structure

References