Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 1437125..1437699 Replicon chromosome
Accession NZ_CP123003
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name vapC Uniprot ID Q92QN4
Locus tag QC756_RS06990 Protein ID WP_010969154.1
Coordinates 1437125..1437490 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92QN3
Locus tag QC756_RS06995 Protein ID WP_010969155.1
Coordinates 1437484..1437699 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS06965 (QC756_06965) 1432265..1433707 + 1443 WP_010969150.1 NADH-quinone oxidoreductase subunit NuoN -
QC756_RS06970 (QC756_06970) 1433704..1434471 + 768 WP_003531861.1 biotin--[acetyl-CoA-carboxylase] ligase -
QC756_RS06975 (QC756_06975) 1434499..1436166 + 1668 WP_010969151.1 ribonuclease J -
QC756_RS06980 (QC756_06980) 1436225..1436629 + 405 WP_010969152.1 methylmalonyl-CoA epimerase -
QC756_RS06985 (QC756_06985) 1436769..1437038 + 270 WP_014526683.1 DUF1467 family protein -
QC756_RS06990 (QC756_06990) 1437125..1437490 - 366 WP_010969154.1 type II toxin-antitoxin system VapC family toxin Toxin
QC756_RS06995 (QC756_06995) 1437484..1437699 - 216 WP_010969155.1 ribbon-helix-helix protein, CopG family Antitoxin
QC756_RS07000 (QC756_07000) 1437767..1437994 - 228 WP_017264047.1 hypothetical protein -
QC756_RS07005 (QC756_07005) 1438410..1439738 + 1329 WP_003531873.1 proline--tRNA ligase -
QC756_RS07010 (QC756_07010) 1439759..1441069 + 1311 WP_014529722.1 lipoprotein-releasing ABC transporter permease subunit -
QC756_RS07015 (QC756_07015) 1441087..1441773 + 687 WP_010969157.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13592.57 Da        Isoelectric Point: 5.1787

>T278334 WP_010969154.1 NZ_CP123003:c1437490-1437125 [Sinorhizobium meliloti]
MVGALFDTNILIDHLNAVPQAHKELDRFENRAISIITWMEVMVGADAELVEPTRRFLDGFETIALNDEIANRAVTLRRAH
RIKLPDAVIWATAQTAGRLLVTRNTKDFPADDPGIREPYAV

Download         Length: 366 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8381.51 Da        Isoelectric Point: 8.6052

>AT278334 WP_010969155.1 NZ_CP123003:c1437699-1437484 [Sinorhizobium meliloti]
MRALIDMNDTQVEALDTLAKRVRRSRAALIREAIDDYLNRHHREQIEDGFGLWGKRKVDGLAYQEKVRGEW

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92QN4

Antitoxin

Source ID Structure
AlphaFold DB Q92QN3

References