278332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 871025..871665 Replicon chromosome
Accession NZ_CP123003
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name vapC Uniprot ID H0G6N1
Locus tag QC756_RS04135 Protein ID WP_003533691.1
Coordinates 871025..871411 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0G6N0
Locus tag QC756_RS04140 Protein ID WP_003533689.1
Coordinates 871411..871665 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS04110 (QC756_04110) 866489..866968 + 480 WP_003537307.1 GNAT family N-acetyltransferase -
QC756_RS04115 (QC756_04115) 867012..867461 - 450 WP_003537305.1 nucleoside deaminase -
QC756_RS04120 (QC756_04120) 867536..869257 + 1722 WP_010968830.1 pseudouridine synthase -
QC756_RS04125 (QC756_04125) 869264..869824 + 561 WP_010968831.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
QC756_RS04130 (QC756_04130) 869897..870796 + 900 WP_010968832.1 patatin-like phospholipase family protein -
QC756_RS04135 (QC756_04135) 871025..871411 - 387 WP_003533691.1 type II toxin-antitoxin system VapC family toxin Toxin
QC756_RS04140 (QC756_04140) 871411..871665 - 255 WP_003533689.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QC756_RS04145 (QC756_04145) 871804..873636 - 1833 WP_010968833.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
QC756_RS04150 (QC756_04150) 873788..875134 + 1347 WP_010968834.1 TldD/PmbA family protein -
QC756_RS04155 (QC756_04155) 875243..876061 + 819 WP_010968835.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
QC756_RS04160 (QC756_04160) 876122..876358 + 237 WP_003533684.1 DUF4170 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13904.77 Da        Isoelectric Point: 4.5716

>T278332 WP_003533691.1 NZ_CP123003:c871411-871025 [Sinorhizobium meliloti]
MVIDTSAIAAIAFNEQEAGSFREKIADDPVRLISAATALEAAMVIETRLGEAAGAELDLWLYKANVEIVAVTAEHMDQAR
RAWRRFGKGRHPAGLNFGDCFSYALAFLTNEPLLFKGSDFSQTDIPAA

Download         Length: 387 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9472.63 Da        Isoelectric Point: 4.8660

>AT278332 WP_003533689.1 NZ_CP123003:c871665-871411 [Sinorhizobium meliloti]
MALSIKDTETEQLARTLARRTGESITLATKRALEERLRRTDTAARRAALLEDLEAIQRRWNAMPVLDSRSSDDIIGYDED
GLPS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G6N1

Antitoxin

Source ID Structure
AlphaFold DB H0G6N0

References